PT  - JOURNAL ARTICLE
AU  - Reijerkerk, Arie
AU  - Lopez-Ramirez, M. Alejandro
AU  - van het Hof, Bert
AU  - Drexhage, Joost A.R.
AU  - Kamphuis, Wouter W.
AU  - Kooij, Gijs
AU  - Vos, Joost B.
AU  - van der Pouw Kraan, Tineke C.T.M.
AU  - van Zonneveld, Anton J.
AU  - Horrevoets, Anton J.
AU  - Prat, Alexandre
AU  - Romero, Ignacio A.
AU  - de Vries, Helga E.
TI  - MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis
AID  - 10.1523/JNEUROSCI.3965-12.2013
DP  - 2013 Apr 17
TA  - The Journal of Neuroscience
PG  - 6857--6863
VI  - 33
IP  - 16
4099  - http://www.jneurosci.org/content/33/16/6857.short
4100  - http://www.jneurosci.org/content/33/16/6857.full
SO  - J. Neurosci.2013 Apr 17; 33
AB  - Blood–brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.