RT Journal Article
SR Electronic
T1 Motor Skill Training Induces Coordinated Strengthening and Weakening between Neighboring Synapses
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 9794
OP 9799
DO 10.1523/JNEUROSCI.0848-12.2013
VO 33
IS 23
A1 Lee, Kea Joo
A1 Park, In Sung
A1 Kim, Hyun
A1 Greenough, William T.
A1 Pak, Daniel T. S.
A1 Rhyu, Im Joo
YR 2013
UL http://www.jneurosci.org/content/33/23/9794.abstract
AB Motor skill training promotes the formation of parallel fiber multiple-synapse boutons (MSBs) contacting dendritic spine pairs of Purkinje cells in the rat cerebellum. However, the dendritic origin of such spine pairs is unknown. Here, we used three-dimensional electron microscopy reconstruction of synaptic connectivity to demonstrate that motor skill training selectively induced MSBs contacting two spines arising from the same dendrite, consistent with strengthening of local synaptic efficacy. However, excitatory synapses near MSBs were smaller in motor-trained animals, suggesting compensatory depression of MSB-neighbor synapses. Concerted strengthening and weakening of adjacent synapses may enhance synaptic weight differences for information encoding while maintaining stable overall activity levels within local dendritic segments.