RT Journal Article
SR Electronic
T1 Reduced Striatal Responses to Reward Prediction Errors in Older Compared with Younger Adults
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 9905
OP 9912
DO 10.1523/JNEUROSCI.2942-12.2013
VO 33
IS 24
A1 Eppinger, Ben
A1 Schuck, Nicolas W.
A1 Nystrom, Leigh E.
A1 Cohen, Jonathan D.
YR 2013
UL http://www.jneurosci.org/content/33/24/9905.abstract
AB We examined whether older adults differ from younger adults in how they learn from rewarding and aversive outcomes. Human participants were asked to either learn to choose actions that lead to monetary reward or learn to avoid actions that lead to monetary losses. To examine age differences in the neurophysiological mechanisms of learning, we applied a combination of computational modeling and fMRI. Behavioral results showed age-related impairments in learning from reward but not in learning from monetary losses. Consistent with these results, we observed age-related reductions in BOLD activity during learning from reward in the ventromedial PFC. Furthermore, the model-based fMRI analysis revealed a reduced responsivity of the ventral striatum to reward prediction errors during learning in older than younger adults. This age-related reduction in striatal sensitivity to reward prediction errors may result from a decline in phasic dopaminergic learning signals in the elderly.