PT  - JOURNAL ARTICLE
AU  - Rasmussen, Anders
AU  - Jirenhed, Dan-Anders
AU  - Zucca, Riccardo
AU  - Johansson, Fredrik
AU  - Svensson, Pär
AU  - Hesslow, Germund
TI  - Number of Spikes in Climbing Fibers Determines the Direction of Cerebellar Learning
AID  - 10.1523/JNEUROSCI.1527-13.2013
DP  - 2013 Aug 14
TA  - The Journal of Neuroscience
PG  - 13436--13440
VI  - 33
IP  - 33
4099  - http://www.jneurosci.org/content/33/33/13436.short
4100  - http://www.jneurosci.org/content/33/33/13436.full
SO  - J. Neurosci.2013 Aug 14; 33
AB  - Cerebellar learning requires context information from mossy fibers and a teaching signal through the climbing fibers from the inferior olive. Although the inferior olive fires in bursts, virtually all studies have used a teaching signal consisting of a single pulse. Following a number of failed attempts to induce cerebellar learning in decerebrate ferrets with a nonburst signal, we tested the effect of varying the number of pulses in the climbing fiber teaching signal. The results show that training with a single pulse in a conditioning paradigm in vivo does not result in learning, but rather causes extinction of a previously learned response.