RT Journal Article
SR Electronic
T1 Number of Spikes in Climbing Fibers Determines the Direction of Cerebellar Learning
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 13436
OP 13440
DO 10.1523/JNEUROSCI.1527-13.2013
VO 33
IS 33
A1 Rasmussen, Anders
A1 Jirenhed, Dan-Anders
A1 Zucca, Riccardo
A1 Johansson, Fredrik
A1 Svensson, Pär
A1 Hesslow, Germund
YR 2013
UL http://www.jneurosci.org/content/33/33/13436.abstract
AB Cerebellar learning requires context information from mossy fibers and a teaching signal through the climbing fibers from the inferior olive. Although the inferior olive fires in bursts, virtually all studies have used a teaching signal consisting of a single pulse. Following a number of failed attempts to induce cerebellar learning in decerebrate ferrets with a nonburst signal, we tested the effect of varying the number of pulses in the climbing fiber teaching signal. The results show that training with a single pulse in a conditioning paradigm in vivo does not result in learning, but rather causes extinction of a previously learned response.