TY - JOUR T1 - Perivascular Fibroblasts Form the Fibrotic Scar after Contusive Spinal Cord Injury JF - The Journal of Neuroscience JO - J. Neurosci. SP - 13882 LP - 13887 DO - 10.1523/JNEUROSCI.2524-13.2013 VL - 33 IS - 34 AU - Cynthia Soderblom AU - Xueting Luo AU - Ezra Blumenthal AU - Eric Bray AU - Kirill Lyapichev AU - Jose Ramos AU - Vidhya Krishnan AU - Catherine Lai-Hsu AU - Kevin K. Park AU - Pantelis Tsoulfas AU - Jae K. Lee Y1 - 2013/08/21 UR - http://www.jneurosci.org/content/33/34/13882.abstract N2 - Injury to the CNS leads to formation of scar tissue, which is important in sealing the lesion and inhibiting axon regeneration. The fibrotic scar that comprises a dense extracellular matrix is thought to originate from meningeal cells surrounding the CNS. However, using transgenic mice, we demonstrate that perivascular collagen1α1 cells are the main source of the cellular composition of the fibrotic scar after contusive spinal cord injury in which the dura remains intact. Using genetic lineage tracing, light sheet fluorescent microscopy, and antigenic profiling, we identify collagen1α1 cells as perivascular fibroblasts that are distinct from pericytes. Our results identify collagen1α1 cells as a novel source of the fibrotic scar after spinal cord injury and shift the focus from the meninges to the vasculature during scar formation. ER -