RT Journal Article
SR Electronic
T1 Ventral Tegmental Dopamine Dysregulation Prevents Appetitive Memory Destabilization
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 14205
OP 14210
DO 10.1523/JNEUROSCI.1614-13.2013
VO 33
IS 35
A1 Amy C. Reichelt
A1 Marc T. Exton-McGuinness
A1 Jonathan L.C. Lee
YR 2013
UL http://www.jneurosci.org/content/33/35/14205.abstract
AB Through the process of reconsolidation, memories can be updated to maintain their relevance. To reconsolidate, a memory must first be destabilized in a process that we have hypothesized is initiated by a prediction error signal. Here we demonstrate that dysregulation of ventral tegmental area (VTA) signaling, which is thought to mediate prediction errors, prevented the destabilization of an appetitive goal-tracking memory in rats. We additionally show that intra-VTA infusion of either the competitive NMDA antagonist AP5 or the noncompetitive NMDA antagonist MK-801 does not selectively disrupt reconsolidation, indicating that the VTA may not be an important neural locus of reconsolidation-related neural plasticity.