PT - JOURNAL ARTICLE AU - Marik, Sally A. AU - Olsen, Olav AU - Tessier-Lavigne, Marc AU - Gilbert, Charles D. TI - Death Receptor 6 Regulates Adult Experience-Dependent Cortical Plasticity AID - 10.1523/JNEUROSCI.2398-13.2013 DP - 2013 Sep 18 TA - The Journal of Neuroscience PG - 14998--15003 VI - 33 IP - 38 4099 - http://www.jneurosci.org/content/33/38/14998.short 4100 - http://www.jneurosci.org/content/33/38/14998.full SO - J. Neurosci.2013 Sep 18; 33 AB - Sensory experience alters cortical circuitry by parallel processes of axon outgrowth and pruning, but the mechanisms that control these rearrangements are poorly understood. Using in vivo 2-photon longitudinal imaging, we found a marked reduction in axonal pruning in somatosensory cortex of mice with a knock-out of the DR6 gene, which codes for Death Receptor 6. This effect was seen for both long-range horizontal excitatory connections and for the axons of inhibitory neurons. These results identify a new pathway governing axonal plasticity associated with experience-dependent changes in cortical maps.