RT Journal Article SR Electronic T1 Death Receptor 6 Regulates Adult Experience-Dependent Cortical Plasticity JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 14998 OP 15003 DO 10.1523/JNEUROSCI.2398-13.2013 VO 33 IS 38 A1 Marik, Sally A. A1 Olsen, Olav A1 Tessier-Lavigne, Marc A1 Gilbert, Charles D. YR 2013 UL http://www.jneurosci.org/content/33/38/14998.abstract AB Sensory experience alters cortical circuitry by parallel processes of axon outgrowth and pruning, but the mechanisms that control these rearrangements are poorly understood. Using in vivo 2-photon longitudinal imaging, we found a marked reduction in axonal pruning in somatosensory cortex of mice with a knock-out of the DR6 gene, which codes for Death Receptor 6. This effect was seen for both long-range horizontal excitatory connections and for the axons of inhibitory neurons. These results identify a new pathway governing axonal plasticity associated with experience-dependent changes in cortical maps.