TY - JOUR T1 - Death Receptor 6 Regulates Adult Experience-Dependent Cortical Plasticity JF - The Journal of Neuroscience JO - J. Neurosci. SP - 14998 LP - 15003 DO - 10.1523/JNEUROSCI.2398-13.2013 VL - 33 IS - 38 AU - Sally A. Marik AU - Olav Olsen AU - Marc Tessier-Lavigne AU - Charles D. Gilbert Y1 - 2013/09/18 UR - http://www.jneurosci.org/content/33/38/14998.abstract N2 - Sensory experience alters cortical circuitry by parallel processes of axon outgrowth and pruning, but the mechanisms that control these rearrangements are poorly understood. Using in vivo 2-photon longitudinal imaging, we found a marked reduction in axonal pruning in somatosensory cortex of mice with a knock-out of the DR6 gene, which codes for Death Receptor 6. This effect was seen for both long-range horizontal excitatory connections and for the axons of inhibitory neurons. These results identify a new pathway governing axonal plasticity associated with experience-dependent changes in cortical maps. ER -