PT  - JOURNAL ARTICLE
AU  - Clark, Luke
AU  - Averbeck, Bruno
AU  - Payer, Doris
AU  - Sescousse, Guillaume
AU  - Winstanley, Catharine A.
AU  - Xue, Gui
TI  - Pathological Choice: The Neuroscience of Gambling and Gambling Addiction
AID  - 10.1523/JNEUROSCI.3231-13.2013
DP  - 2013 Nov 06
TA  - The Journal of Neuroscience
PG  - 17617--17623
VI  - 33
IP  - 45
4099  - http://www.jneurosci.org/content/33/45/17617.short
4100  - http://www.jneurosci.org/content/33/45/17617.full
SO  - J. Neurosci.2013 Nov 06; 33
AB  - Gambling is pertinent to neuroscience research for at least two reasons. First, gambling is a naturalistic and pervasive example of risky decision making, and thus gambling games can provide a paradigm for the investigation of human choice behavior and “irrationality.” Second, excessive gambling involvement (i.e., pathological gambling) is currently conceptualized as a behavioral addiction, and research on this condition may provide insights into addictive mechanisms in the absence of exogenous drug effects. This article is a summary of topics covered in a Society for Neuroscience minisymposium, focusing on recent advances in understanding the neural basis of gambling behavior, including translational findings in rodents and nonhuman primates, which have begun to delineate neural circuitry and neurochemistry involved.