RT Journal Article SR Electronic T1 Pathological Choice: The Neuroscience of Gambling and Gambling Addiction JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 17617 OP 17623 DO 10.1523/JNEUROSCI.3231-13.2013 VO 33 IS 45 A1 Luke Clark A1 Bruno Averbeck A1 Doris Payer A1 Guillaume Sescousse A1 Catharine A. Winstanley A1 Gui Xue YR 2013 UL http://www.jneurosci.org/content/33/45/17617.abstract AB Gambling is pertinent to neuroscience research for at least two reasons. First, gambling is a naturalistic and pervasive example of risky decision making, and thus gambling games can provide a paradigm for the investigation of human choice behavior and “irrationality.” Second, excessive gambling involvement (i.e., pathological gambling) is currently conceptualized as a behavioral addiction, and research on this condition may provide insights into addictive mechanisms in the absence of exogenous drug effects. This article is a summary of topics covered in a Society for Neuroscience minisymposium, focusing on recent advances in understanding the neural basis of gambling behavior, including translational findings in rodents and nonhuman primates, which have begun to delineate neural circuitry and neurochemistry involved.