RT Journal Article
SR Electronic
T1 Neuroestradiol in the Hypothalamus Contributes to the Regulation of Gonadotropin Releasing Hormone Release
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 19051
OP 19059
DO 10.1523/JNEUROSCI.3878-13.2013
VO 33
IS 49
A1 Kenealy, Brian P.
A1 Kapoor, Amita
A1 Guerriero, Kathryn A.
A1 Keen, Kim L.
A1 Garcia, James P.
A1 Kurian, Joseph R.
A1 Ziegler, Toni E.
A1 Terasawa, Ei
YR 2013
UL http://www.jneurosci.org/content/33/49/19051.abstract
AB Release of gonadotropin releasing hormone (GnRH) from the medial basal hypothalamus (MBH)/median eminence region (S-ME) is essential for normal reproductive function. GnRH release is profoundly regulated by the negative and positive feedback effects of ovarian estradiol (E2). Here we report that neuroestradiol, released in the S-ME, also directly influences GnRH release in ovariectomized female monkeys, in which the ovarian source of E2 is removed. We found that (1) brief infusion of E2 benzoate (EB) to the S-ME rapidly stimulated release of GnRH and E2 in the S-ME of ovariectomized monkeys, (2) electrical stimulation of the MBH resulted in GnRH release as well as E2 release, and (3) direct infusion of an aromatase inhibitor to the S-ME suppressed spontaneous GnRH release as well as the EB-induced release of GnRH and E2. These findings reveal the importance of neuroestradiol as a neurotransmitter in regulation of GnRH release. How circulating ovarian E2 interacts with hypothalamic neuroestrogens in the control of GnRH release remains to be investigated.