RT Journal Article
SR Electronic
T1 A Transition in Brain State during Propofol-Induced Unconsciousness
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 839
OP 845
DO 10.1523/JNEUROSCI.5813-12.2014
VO 34
IS 3
A1 Eran A. Mukamel
A1 Elvira Pirondini
A1 Behtash Babadi
A1 Kin Foon Kevin Wong
A1 Eric T. Pierce
A1 P. Grace Harrell
A1 John L. Walsh
A1 Andres F. Salazar-Gomez
A1 Sydney S. Cash
A1 Emad N. Eskandar
A1 Veronica S. Weiner
A1 Emery N. Brown
A1 Patrick L. Purdon
YR 2014
UL http://www.jneurosci.org/content/34/3/839.abstract
AB Rhythmic oscillations shape cortical dynamics during active behavior, sleep, and general anesthesia. Cross-frequency phase-amplitude coupling is a prominent feature of cortical oscillations, but its role in organizing conscious and unconscious brain states is poorly understood. Using high-density EEG and intracranial electrocorticography during gradual induction of propofol general anesthesia in humans, we discovered a rapid drug-induced transition between distinct states with opposite phase-amplitude coupling and different cortical source distributions. One state occurs during unconsciousness and may be similar to sleep slow oscillations. A second state occurs at the loss or recovery of consciousness and resembles an enhanced slow cortical potential. These results provide objective electrophysiological landmarks of distinct unconscious brain states, and could be used to help improve EEG-based monitoring for general anesthesia.