PT - JOURNAL ARTICLE AU - Zhu, Jinmin AU - Lee, Kevin P. AU - Spencer, Thomas J. AU - Biederman, Joseph AU - Bhide, Pradeep G. TI - Transgenerational Transmission of Hyperactivity in a Mouse Model of ADHD AID - 10.1523/JNEUROSCI.4402-13.2014 DP - 2014 Feb 19 TA - The Journal of Neuroscience PG - 2768--2773 VI - 34 IP - 8 4099 - http://www.jneurosci.org/content/34/8/2768.short 4100 - http://www.jneurosci.org/content/34/8/2768.full SO - J. Neurosci.2014 Feb 19; 34 AB - Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral disorder affecting children and adults. Genetic and environmental factors are associated with the etiology of ADHD. Among the environmental factors, exposure of the developing brain to nicotine is considered a major risk factor. Recent evidence suggests that environmental influences on the brain and behavior may be transmitted from one generation to the next. We used a prenatal nicotine exposure (PNE) mouse model of ADHD to test the hypothesis that PNE-induced hyperactivity, a proxy for human ADHD phenotype, is transmitted from one generation to the next. Our data reveal transgenerational transmission of PNE-induced hyperactivity in mice via the maternal but not the paternal line of descent. We suggest that transgenerational transmission is a plausible mechanism for propagation of environmentally induced ADHD phenotypes in the population.