PT  - JOURNAL ARTICLE
AU  - Zhu, Jinmin
AU  - Lee, Kevin P.
AU  - Spencer, Thomas J.
AU  - Biederman, Joseph
AU  - Bhide, Pradeep G.
TI  - Transgenerational Transmission of Hyperactivity in a Mouse Model of ADHD
AID  - 10.1523/JNEUROSCI.4402-13.2014
DP  - 2014 Feb 19
TA  - The Journal of Neuroscience
PG  - 2768--2773
VI  - 34
IP  - 8
4099  - http://www.jneurosci.org/content/34/8/2768.short
4100  - http://www.jneurosci.org/content/34/8/2768.full
SO  - J. Neurosci.2014 Feb 19; 34
AB  - Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral disorder affecting children and adults. Genetic and environmental factors are associated with the etiology of ADHD. Among the environmental factors, exposure of the developing brain to nicotine is considered a major risk factor. Recent evidence suggests that environmental influences on the brain and behavior may be transmitted from one generation to the next. We used a prenatal nicotine exposure (PNE) mouse model of ADHD to test the hypothesis that PNE-induced hyperactivity, a proxy for human ADHD phenotype, is transmitted from one generation to the next. Our data reveal transgenerational transmission of PNE-induced hyperactivity in mice via the maternal but not the paternal line of descent. We suggest that transgenerational transmission is a plausible mechanism for propagation of environmentally induced ADHD phenotypes in the population.