TY - JOUR T1 - Transgenerational Transmission of Hyperactivity in a Mouse Model of ADHD JF - The Journal of Neuroscience JO - J. Neurosci. SP - 2768 LP - 2773 DO - 10.1523/JNEUROSCI.4402-13.2014 VL - 34 IS - 8 AU - Jinmin Zhu AU - Kevin P. Lee AU - Thomas J. Spencer AU - Joseph Biederman AU - Pradeep G. Bhide Y1 - 2014/02/19 UR - http://www.jneurosci.org/content/34/8/2768.abstract N2 - Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral disorder affecting children and adults. Genetic and environmental factors are associated with the etiology of ADHD. Among the environmental factors, exposure of the developing brain to nicotine is considered a major risk factor. Recent evidence suggests that environmental influences on the brain and behavior may be transmitted from one generation to the next. We used a prenatal nicotine exposure (PNE) mouse model of ADHD to test the hypothesis that PNE-induced hyperactivity, a proxy for human ADHD phenotype, is transmitted from one generation to the next. Our data reveal transgenerational transmission of PNE-induced hyperactivity in mice via the maternal but not the paternal line of descent. We suggest that transgenerational transmission is a plausible mechanism for propagation of environmentally induced ADHD phenotypes in the population. ER -