RT Journal Article
SR Electronic
T1 Transgenerational Transmission of Hyperactivity in a Mouse Model of ADHD
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 2768
OP 2773
DO 10.1523/JNEUROSCI.4402-13.2014
VO 34
IS 8
A1 Zhu, Jinmin
A1 Lee, Kevin P.
A1 Spencer, Thomas J.
A1 Biederman, Joseph
A1 Bhide, Pradeep G.
YR 2014
UL http://www.jneurosci.org/content/34/8/2768.abstract
AB Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral disorder affecting children and adults. Genetic and environmental factors are associated with the etiology of ADHD. Among the environmental factors, exposure of the developing brain to nicotine is considered a major risk factor. Recent evidence suggests that environmental influences on the brain and behavior may be transmitted from one generation to the next. We used a prenatal nicotine exposure (PNE) mouse model of ADHD to test the hypothesis that PNE-induced hyperactivity, a proxy for human ADHD phenotype, is transmitted from one generation to the next. Our data reveal transgenerational transmission of PNE-induced hyperactivity in mice via the maternal but not the paternal line of descent. We suggest that transgenerational transmission is a plausible mechanism for propagation of environmentally induced ADHD phenotypes in the population.