TY - JOUR T1 - ATP Hydrolysis Is Critically Required for Function of Ca<sub>V</sub>1.3 Channels in Cochlear Inner Hair Cells via Fueling Ca<sup>2+</sup> Clearance JF - The Journal of Neuroscience JO - J. Neurosci. SP - 6843 LP - 6848 DO - 10.1523/JNEUROSCI.4990-13.2014 VL - 34 IS - 20 AU - Simon Weiler AU - Stefanie Krinner AU - Aaron B. Wong AU - Tobias Moser AU - Tina Pangršič Y1 - 2014/05/14 UR - http://www.jneurosci.org/content/34/20/6843.abstract N2 - Sound encoding is mediated by Ca2+ influx-evoked release of glutamate at the ribbon synapse of inner hair cells. Here we studied the role of ATP in this process focusing on Ca2+ current through CaV1.3 channels and Ca2+ homeostasis in mouse inner hair cells. Patch-clamp recordings and Ca2+ imaging demonstrate that hydrolyzable ATP is essential to maintain synaptic Ca2+ influx in inner hair cells via fueling Ca2+-ATPases to avoid an increase in cytosolic [Ca2+] and subsequent Ca2+/calmodulin-dependent inactivation of CaV1.3 channels. ER -