PT  - JOURNAL ARTICLE
AU  - Simon Weiler
AU  - Stefanie Krinner
AU  - Aaron B. Wong
AU  - Tobias Moser
AU  - Tina Pangršič
TI  - ATP Hydrolysis Is Critically Required for Function of Ca<sub>V</sub>1.3 Channels in Cochlear Inner Hair Cells via Fueling Ca<sup>2+</sup> Clearance
AID  - 10.1523/JNEUROSCI.4990-13.2014
DP  - 2014 May 14
TA  - The Journal of Neuroscience
PG  - 6843--6848
VI  - 34
IP  - 20
4099  - http://www.jneurosci.org/content/34/20/6843.short
4100  - http://www.jneurosci.org/content/34/20/6843.full
SO  - J. Neurosci.2014 May 14; 34
AB  - Sound encoding is mediated by Ca2+ influx-evoked release of glutamate at the ribbon synapse of inner hair cells. Here we studied the role of ATP in this process focusing on Ca2+ current through CaV1.3 channels and Ca2+ homeostasis in mouse inner hair cells. Patch-clamp recordings and Ca2+ imaging demonstrate that hydrolyzable ATP is essential to maintain synaptic Ca2+ influx in inner hair cells via fueling Ca2+-ATPases to avoid an increase in cytosolic [Ca2+] and subsequent Ca2+/calmodulin-dependent inactivation of CaV1.3 channels.