PT  - JOURNAL ARTICLE
AU  - Dhananjay Bambah-Mukku
AU  - Alessio Travaglia
AU  - Dillon Y. Chen
AU  - Gabriella Pollonini
AU  - Cristina M. Alberini
TI  - A Positive Autoregulatory BDNF Feedback Loop via C/EBPβ Mediates Hippocampal Memory Consolidation
AID  - 10.1523/JNEUROSCI.0324-14.2014
DP  - 2014 Sep 10
TA  - The Journal of Neuroscience
PG  - 12547--12559
VI  - 34
IP  - 37
4099  - http://www.jneurosci.org/content/34/37/12547.short
4100  - http://www.jneurosci.org/content/34/37/12547.full
SO  - J. Neurosci.2014 Sep 10; 34
AB  - Little is known about the temporal progression and regulation of the mechanisms underlying memory consolidation. Brain-derived-neurotrophic-factor (BDNF) has been shown to mediate the maintenance of memory consolidation, but the mechanisms of this regulation remain unclear. Using inhibitory avoidance (IA) in rats, here we show that a hippocampal BDNF-positive autoregulatory feedback loop via CCAAT-enhancer binding protein β (C/EBPβ) is necessary to mediate memory consolidation. At training, a very rapid, learning-induced requirement of BDNF accompanied by rapid de novo translation controls the induction of a persistent activation of cAMP-response element binding-protein (CREB) and C/EBPβ expression. The latter, in turn, controls an increase in expression of bdnf exon IV transcripts and BDNF protein, both of which are necessary and, together with the initial BDNF requirement, mediate memory consolidation. The autoregulatory loop terminates by 48 h after training with decreased C/EBPβ and pCREB and increased methyl-CpG binding protein-2, histone-deacetylase-2, and switch-independent-3a binding at the bdnf exon IV promoter.