RT Journal Article
SR Electronic
T1 Alpha-Band Hypersynchronization in Progressive Mild Cognitive Impairment: A Magnetoencephalography Study
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 14551
OP 14559
DO 10.1523/JNEUROSCI.0964-14.2014
VO 34
IS 44
A1 María Eugenía López
A1 Ricardo Bruña
A1 Sara Aurtenetxe
A1 José Ángel Pineda-Pardo
A1 Alberto Marcos
A1 Juan Arrazola
A1 Ana Isabel Reinoso
A1 Pedro Montejo
A1 Ricardo Bajo
A1 Fernando Maestú
YR 2014
UL http://www.jneurosci.org/content/34/44/14551.abstract
AB People with mild cognitive impairment (MCI) show a high risk to develop Alzheimer's disease (AD; Petersen et al., 2001). Nonetheless, there is a lack of studies about how functional connectivity patterns may distinguish between progressive (pMCI) and stable (sMCI) MCI patients. To examine whether there were differences in functional connectivity between groups, MEG eyes-closed recordings from 30 sMCI and 19 pMCI subjects were compared. The average conversion time of pMCI was 1 year, so they were considered as fast converters. To this end, functional connectivity in different frequency bands was assessed with phase locking value in source space. Then the significant differences between both groups were correlated with neuropsychological scores and entorhinal, parahippocampal, and hippocampal volumes. Both groups did not differ in age, gender, or educational level. pMCI patients obtained lower scores in episodic and semantic memory and also in executive functioning. At the structural level, there were no differences in hippocampal volume, although some were found in left entorhinal volume between both groups. Additionally, pMCI patients exhibit a higher synchronization in the alpha band between the right anterior cingulate and temporo-occipital regions than sMCI subjects. This hypersynchronization was inversely correlated with cognitive performance, both hippocampal volumes, and left entorhinal volume. The increase in phase synchronization between the right anterior cingulate and temporo-occipital areas may be predictive of conversion from MCI to AD.