RT Journal Article
SR Electronic
T1 Dopamine Modulates the Neural Representation of Subjective Value of Food in Hungry Subjects
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 16856
OP 16864
DO 10.1523/JNEUROSCI.2051-14.2014
VO 34
IS 50
A1 Nenad Medic
A1 Hisham Ziauddeen
A1 Martin D. Vestergaard
A1 Elana Henning
A1 Wolfram Schultz
A1 I. Sadaf Farooqi
A1 Paul C. Fletcher
YR 2014
UL http://www.jneurosci.org/content/34/50/16856.abstract
AB Although there is a rich literature on the role of dopamine in value learning, much less is known about its role in using established value estimations to shape decision-making. Here we investigated the effect of dopaminergic modulation on value-based decision-making for food items in fasted healthy human participants. The Becker-deGroot-Marschak auction, which assesses subjective value, was examined in conjunction with pharmacological fMRI using a dopaminergic agonist and an antagonist. We found that dopamine enhanced the neural response to value in the inferior parietal gyrus/intraparietal sulcus, and that this effect predominated toward the end of the valuation process when an action was needed to record the value. Our results suggest that dopamine is involved in acting upon the decision, providing additional insight to the mechanisms underlying impaired decision-making in healthy individuals and clinical populations with reduced dopamine levels.