TY - JOUR T1 - Slow Oscillations during Sleep Coordinate Interregional Communication in Cortical Networks JF - The Journal of Neuroscience JO - J. Neurosci. SP - 16890 LP - 16901 DO - 10.1523/JNEUROSCI.1953-14.2014 VL - 34 IS - 50 AU - Roy Cox AU - Joram van Driel AU - Marieke de Boer AU - Lucia M. Talamini Y1 - 2014/12/10 UR - http://www.jneurosci.org/content/34/50/16890.abstract N2 - Large-amplitude sleep slow oscillations group faster neuronal oscillations and are of functional relevance for memory performance. However, relatively little is known about the impact of slow oscillations on functionally coupled networks. Here, we provide a comprehensive view on how human slow oscillatory dynamics influence various measures of brain processing. We demonstrate that slow oscillations coordinate interregional cortical communication, as assessed by phase synchrony in the sleep spindle frequency range and cross-frequency coupling between spindle and beta activity. Furthermore, we show that the organizing role of slow oscillations is restricted to circumscribed topographical areas. These findings add importantly to our basic understanding of the orchestrating role of slow oscillations. In addition, they are of considerable relevance for accounts of sleep-dependent memory reprocessing and consolidation. ER -