PT  - JOURNAL ARTICLE
AU  - Rajendran, Lawrence
AU  - Bali, Jitin
AU  - Barr, Maureen M.
AU  - Court, Felipe A.
AU  - Krämer-Albers, Eva-Maria
AU  - Picou, Frederic
AU  - Raposo, Graça
AU  - van der Vos, Kristan E.
AU  - van Niel, Guillaume
AU  - Wang, Juan
AU  - Breakefield, Xandra O.
TI  - Emerging Roles of Extracellular Vesicles in the Nervous System
AID  - 10.1523/JNEUROSCI.3258-14.2014
DP  - 2014 Nov 12
TA  - The Journal of Neuroscience
PG  - 15482--15489
VI  - 34
IP  - 46
4099  - http://www.jneurosci.org/content/34/46/15482.short
4100  - http://www.jneurosci.org/content/34/46/15482.full
SO  - J. Neurosci.2014 Nov 12; 34
AB  - Information exchange executed by extracellular vesicles, including exosomes, is a newly described form of intercellular communication important in the development and physiology of neural systems. These vesicles can be released from cells, are packed with information including signaling proteins and both coding and regulatory RNAs, and can be taken up by target cells, thereby facilitating the transfer of multilevel information. Recent studies demonstrate their critical role in physiological processes, including nerve regeneration, synaptic function, and behavior. These vesicles also have a sinister role in the propagation of toxic amyloid proteins in neurodegenerative conditions, including prion diseases and Alzheimer's and Parkinson's diseases, in inducing neuroinflammation by exchange of information between the neurons and glia, as well as in aiding tumor progression in the brain by subversion of normal cells. This article provides a summary of topics covered in a symposium and is not meant to be a comprehensive review of the subject.