RT Journal Article
SR Electronic
T1 Emerging Roles of Extracellular Vesicles in the Nervous System
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 15482
OP 15489
DO 10.1523/JNEUROSCI.3258-14.2014
VO 34
IS 46
A1 Lawrence Rajendran
A1 Jitin Bali
A1 Maureen M. Barr
A1 Felipe A. Court
A1 Eva-Maria Krämer-Albers
A1 Frederic Picou
A1 Graça Raposo
A1 Kristan E. van der Vos
A1 Guillaume van Niel
A1 Juan Wang
A1 Xandra O. Breakefield
YR 2014
UL http://www.jneurosci.org/content/34/46/15482.abstract
AB Information exchange executed by extracellular vesicles, including exosomes, is a newly described form of intercellular communication important in the development and physiology of neural systems. These vesicles can be released from cells, are packed with information including signaling proteins and both coding and regulatory RNAs, and can be taken up by target cells, thereby facilitating the transfer of multilevel information. Recent studies demonstrate their critical role in physiological processes, including nerve regeneration, synaptic function, and behavior. These vesicles also have a sinister role in the propagation of toxic amyloid proteins in neurodegenerative conditions, including prion diseases and Alzheimer's and Parkinson's diseases, in inducing neuroinflammation by exchange of information between the neurons and glia, as well as in aiding tumor progression in the brain by subversion of normal cells. This article provides a summary of topics covered in a symposium and is not meant to be a comprehensive review of the subject.