RT Journal Article
SR Electronic
T1 Morphometric and Histologic Substrates of Cingulate Integrity in Elders with Exceptional Memory Capacity
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 1781
OP 1791
DO 10.1523/JNEUROSCI.2998-14.2015
VO 35
IS 4
A1 Tamar Gefen
A1 Melanie Peterson
A1 Steven T. Papastefan
A1 Adam Martersteck
A1 Kristen Whitney
A1 Alfred Rademaker
A1 Eileen H. Bigio
A1 Sandra Weintraub
A1 Emily Rogalski
A1 M.-Marsel Mesulam
A1 Changiz Geula
YR 2015
UL http://www.jneurosci.org/content/35/4/1781.abstract
AB This human study is based on an established cohort of “SuperAgers,” 80+-year-old individuals with episodic memory function at a level equal to, or better than, individuals 20–30 years younger. A preliminary investigation using structural brain imaging revealed a region of anterior cingulate cortex that was thicker in SuperAgers compared with healthy 50- to 65-year-olds. Here, we investigated the in vivo structural features of cingulate cortex in a larger sample of SuperAgers and conducted a histologic analysis of this region in postmortem specimens. A region-of-interest MRI structural analysis found cingulate cortex to be thinner in cognitively average 80+ year olds (n = 21) than in the healthy middle-aged group (n = 18). A region of the anterior cingulate cortex in the right hemisphere displayed greater thickness in SuperAgers (n = 31) compared with cognitively average 80+ year olds and also to the much younger healthy 50–60 year olds (p < 0.01). Postmortem investigations were conducted in the cingulate cortex in five SuperAgers, five cognitively average elderly individuals, and five individuals with amnestic mild cognitive impairment. Compared with other subject groups, SuperAgers showed a lower frequency of Alzheimer-type neurofibrillary tangles (p < 0.05). There were no differences in total neuronal size or count between subject groups. Interestingly, relative to total neuronal packing density, there was a higher density of von Economo neurons (p < 0.05), particularly in anterior cingulate regions of SuperAgers. These findings suggest that reduced vulnerability to the age-related emergence of Alzheimer pathology and higher von Economo neuron density in anterior cingulate cortex may represent biological correlates of high memory capacity in advanced old age.