RT Journal Article
SR Electronic
T1 Differential Magnetic Resonance Neurofeedback Modulations across Extrinsic (Visual) and Intrinsic (Default-Mode) Nodes of the Human Cortex
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 2588
OP 2595
DO 10.1523/JNEUROSCI.3098-14.2015
VO 35
IS 6
A1 Harmelech, Tal
A1 Friedman, Doron
A1 Malach, Rafael
YR 2015
UL http://www.jneurosci.org/content/35/6/2588.abstract
AB Previous advances in magnetic resonance imaging allow the analysis of blood oxygen level-dependent signals in real time, thus opening the possibility of feeding an index of these signals back to scanned human participants. However, it is still not known to what extent different cortical networks may differ in their sensitivity to such internally generated neurofeedback (NF). Here, we compare NF efficacy across six cortical regions including: early and high-order visual areas and the posterior parietal lobe, a prominent node of the default mode network (DMN). Our results reveal a consistent difference in NF activation across these areas. Sham controls ruled out a role of attention/arousal in these effects. These differences are suggestive of a relationship to the relative reliance on intrinsic information, moving from early visual cortex (lowest) to the DMN (highest). Interestingly, the visual parahippocampal place area showed NF activation closer to the DMN node. The results are compatible with the notion of the DMN as an intrinsically oriented system.