RT Journal Article
SR Electronic
T1 Brain Amyloid-β Burden Is Associated with Disruption of Intrinsic Functional Connectivity within the Medial Temporal Lobe in Cognitively Normal Elderly
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 3240
OP 3247
DO 10.1523/JNEUROSCI.2092-14.2015
VO 35
IS 7
A1 Zhuang Song
A1 Philip S. Insel
A1 Shannon Buckley
A1 Seghel Yohannes
A1 Adam Mezher
A1 Alix Simonson
A1 Sarah Wilkins
A1 Duygu Tosun
A1 Susanne Mueller
A1 Joel H. Kramer
A1 Bruce L. Miller
A1 Michael W. Weiner
YR 2015
UL http://www.jneurosci.org/content/35/7/3240.abstract
AB The medial temporal lobe is implicated as a key brain region involved in the pathogenesis of Alzheimer's disease (AD) and consequent memory loss. Tau tangle aggregation in this region may develop concurrently with cortical Aβ deposition in preclinical AD, but the pathological relationship between tau and Aβ remains unclear. We used task-free fMRI with a focus on the medical temporal lobe, together with Aβ PET imaging, in cognitively normal elderly human participants. We found that cortical Aβ load was related to disrupted intrinsic functional connectivity of the perirhinal cortex, which is typically the first brain region affected by tauopathies in AD. There was no concurrent association of cortical Aβ load with cognitive performance or brain atrophy. These findings suggest that dysfunction in the medial temporal lobe may represent a very early sign of preclinical AD and may predict future memory loss.