PT  - JOURNAL ARTICLE
AU  - Enric Domènech-Estévez
AU  - Hasna Baloui
AU  - Cendrine Repond
AU  - Katia Rosafio
AU  - Jean-Jacques Médard
AU  - Nicolas Tricaud
AU  - Luc Pellerin
AU  - Roman Chrast
TI  - Distribution of Monocarboxylate Transporters in the Peripheral Nervous System Suggests Putative Roles in Lactate Shuttling and Myelination
AID  - 10.1523/JNEUROSCI.3534-14.2015
DP  - 2015 Mar 11
TA  - The Journal of Neuroscience
PG  - 4151--4156
VI  - 35
IP  - 10
4099  - http://www.jneurosci.org/content/35/10/4151.short
4100  - http://www.jneurosci.org/content/35/10/4151.full
SO  - J. Neurosci.2015 Mar 11; 35
AB  - Lactate, a product of glycolysis, has been shown to play a key role in the metabolic support of neurons/axons in the CNS by both astrocytes and oligodendrocytes through monocarboxylate transporters (MCTs). Despite such importance in the CNS, little is known about MCT expression and lactate function in the PNS. Here we show that mouse MCT1, MCT2, and MCT4 are expressed in the PNS. While DRG neurons express MCT1, myelinating Schwann cells (SCs) coexpress MCT1 and MCT4 in a domain-specific fashion, mainly in regions of noncompact myelin. Interestingly, SC-specific downregulation of MCT1 expression in rat neuron/SC cocultures led to increased myelination, while its downregulation in neurons resulted in a decreased amount of neurofilament. Finally, pure rat SCs grown in the presence of lactate exhibited an increase in the level of expression of the main myelin regulator gene Krox20/Egr2 and the myelin gene P0. These data indicate that lactate homeostasis participates in the regulation of the SC myelination program and reveal that similar to CNS, PNS axon–glial metabolic interactions are most likely mediated by MCTs.