RT Journal Article
SR Electronic
T1 Orbitofrontal Cortex Encodes Memories within Value-Based Schemas and Represents Contexts That Guide Memory Retrieval
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 8333
OP 8344
DO 10.1523/JNEUROSCI.0134-15.2015
VO 35
IS 21
A1 Farovik, Anja
A1 Place, Ryan J.
A1 McKenzie, Sam
A1 Porter, Blake
A1 Munro, Catherine E.
A1 Eichenbaum, Howard
YR 2015
UL http://www.jneurosci.org/content/35/21/8333.abstract
AB There are a substantial number of studies showing that the orbitofrontal cortex links events to reward values, whereas the hippocampus links events to the context in which they occur. Here we asked how the orbitofrontal cortex contributes to memory where context determines the reward values associated with events. After rats learned object–reward associations that differed depending on the spatial context in which the objects were presented, neuronal ensembles in orbitofrontal cortex represented distinct value-based schemas, each composed of a systematic organization of the representations of objects in the contexts and positions where they were associated with reward or nonreward. Orbitofrontal ensembles also represent the different spatial contexts that define the mappings of stimuli to actions that lead to reward or nonreward. These findings, combined with observations on complementary memory representation within the hippocampus, suggest mechanisms through which prefrontal cortex and the hippocampus interact in support of context-guided memory.