RT Journal Article
SR Electronic
T1 New Perspectives for the Rescue of Cognitive Disability in Down Syndrome
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 13843
OP 13852
DO 10.1523/JNEUROSCI.2775-15.2015
VO 35
IS 41
A1 Renata Bartesaghi
A1 Tarik F. Haydar
A1 Jean Maurice Delabar
A1 Mara Dierssen
A1 Carmen Martínez-Cué
A1 Diana W. Bianchi
YR 2015
UL http://www.jneurosci.org/content/35/41/13843.abstract
AB Down syndrome (DS) is a relatively common genetic condition caused by the triplication of human chromosome 21. No therapies currently exist for the rescue of neurocognitive impairment in DS. This review presents exciting findings showing that it is possible to restore brain development and cognitive performance in mouse models of DS with therapies that can also apply to humans. This knowledge provides a potential breakthrough for the prevention of intellectual disability in DS.