RT Journal Article
SR Electronic
T1 Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 10440
OP 10455
DO 10.1523/JNEUROSCI.4343-15.2016
VO 36
IS 40
A1 DiGiovanna, Jack
A1 Dominici, Nadia
A1 Friedli, Lucia
A1 Rigosa, Jacopo
A1 Duis, Simone
A1 Kreider, Julie
A1 Beauparlant, Janine
A1 van den Brand, Rubia
A1 Schieppati, Marco
A1 Micera, Silvestro
A1 Courtine, Grégoire
YR 2016
UL http://www.jneurosci.org/content/36/40/10440.abstract
AB Contrary to cats and primates, cortical contribution to hindlimb locomotor movements is not critical in rats. However, the importance of the motor cortex to regain locomotion after neurological disorders in rats suggests that cortical engagement in hindlimb motor control may depend on the behavioral context. To investigate this possibility, we recorded whole-body kinematics, muscle synergies, and hindlimb motor cortex modulation in freely moving rats performing a range of natural locomotor procedures. We found that the activation of hindlimb motor cortex preceded gait initiation. During overground locomotion, the motor cortex exhibited consistent neuronal population responses that were synchronized with the spatiotemporal activation of hindlimb motoneurons. Behaviors requiring enhanced muscle activity or skilled paw placement correlated with substantial adjustment in neuronal population responses. In contrast, all rats exhibited a reduction of cortical activity during more automated behavior, such as stepping on a treadmill. Despite the facultative role of the motor cortex in the production of locomotion in rats, these results show that the encoding of hindlimb features in motor cortex dynamics is comparable in rats and cats. However, the extent of motor cortex modulations appears linked to the degree of volitional engagement and complexity of the task, reemphasizing the importance of goal-directed behaviors for motor control studies, rehabilitation, and neuroprosthetics.SIGNIFICANCE STATEMENT We mapped the neuronal population responses in the hindlimb motor cortex to hindlimb kinematics and hindlimb muscle synergies across a spectrum of natural locomotion behaviors. Robust task-specific neuronal population responses revealed that the rat motor cortex displays similar modulation as other mammals during locomotion. However, the reduced motor cortex activity during more automated behaviors suggests a relationship between the degree of engagement and task complexity. This relationship emphasizes the importance of the behavioral procedure to engage the motor cortex during motor control studies, gait rehabilitation, and locomotor neuroprosthetic developments in rats.