TY - JOUR T1 - Transplanted Cells Are Essential for the Induction But Not the Expression of Cortical Plasticity JF - The Journal of Neuroscience JO - J. Neurosci. SP - 7529 LP - 7538 DO - 10.1523/JNEUROSCI.1430-19.2019 VL - 39 IS - 38 AU - Mahmood S. Hoseini AU - Benjamin Rakela AU - Quetzal Flores-Ramirez AU - Andrea R. Hasenstaub AU - Arturo Alvarez-Buylla AU - Michael P. Stryker Y1 - 2019/09/18 UR - http://www.jneurosci.org/content/39/38/7529.abstract N2 - Transplantation of even a small number of embryonic inhibitory neurons from the medial ganglionic eminence (MGE) into postnatal visual cortex makes it lose responsiveness to an eye deprived of vision when the transplanted neurons reach the age of the normal critical period of activity-dependent ocular dominance (OD) plasticity. The transplant might induce OD plasticity in the host circuitry or might instead construct a parallel circuit of its own to suppress cortical responses to the deprived eye. We transplanted MGE neurons expressing either archaerhodopsin or channelrhodopsin into the visual cortex of both male and female mice, closed one eyelid for 4–5 d, and, as expected, observed transplant-induced OD plasticity. This plasticity was evident even when the activity of the transplanted cells was suppressed or enhanced optogenetically, demonstrating that the plasticity was produced by changes in the host visual cortex.SIGNIFICANCE STATEMENT Interneuron transplantation into mouse V1 creates a window of heightened plasticity that is quantitatively and qualitatively similar to the normal critical period; that is, short-term occlusion of either eye markedly changes ocular dominance (OD). The underlying mechanism of this process is not known. Transplanted interneurons might either form a separate circuit to maintain the OD shift or might instead trigger changes in the host circuity. We designed experiments to distinguish the two hypotheses. Our findings suggest that while inhibition produced by the transplanted cells triggers this form of plasticity, the host circuity is entirely responsible for maintaining the OD shift. ER -