RT Journal Article
SR Electronic
T1 Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 6289
OP 6308
DO 10.1523/JNEUROSCI.0288-20.2020
VO 40
IS 33
A1 Andreska, Thomas
A1 Rauskolb, Stefanie
A1 Schukraft, Nina
A1 Lüningschrör, Patrick
A1 Sasi, Manju
A1 Signoret-Genest, Jeremy
A1 Behringer, Marcus
A1 Blum, Robert
A1 Sauer, Markus
A1 Tovote, Philip
A1 Sendtner, Michael
YR 2020
UL http://www.jneurosci.org/content/40/33/6289.abstract
AB Motor learning depends on synaptic plasticity between corticostriatal projections and striatal medium spiny neurons. Retrograde tracing from the dorsolateral striatum reveals that both layer II/III and V neurons in the motor cortex express BDNF as a potential regulator of plasticity in corticostriatal projections in male and female mice. The number of these BDNF-expressing cortical neurons and levels of BDNF protein are highest in juvenile mice when adult motor patterns are shaped, while BDNF levels in the adult are low. When mice are trained by physical exercise in the adult, BDNF expression in motor cortex is reinduced, especially in layer II/III projection neurons. Reduced expression of cortical BDNF in 3-month-old mice results in impaired motor learning while space memory is preserved. These findings suggest that activity regulates BDNF expression differentially in layers II/III and V striatal afferents from motor cortex and that cortical BDNF is essential for motor learning.SIGNIFICANCE STATEMENT Motor learning in mice depends on corticostriatal BDNF supply, and regulation of BDNF expression during motor learning is highest in corticostriatal projection neurons in cortical layer II/III.