RT Journal Article
SR Electronic
T1 Cognitive-Affective Functions of the Cerebellum
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 7554
OP 7564
DO 10.1523/JNEUROSCI.1451-23.2023
VO 43
IS 45
A1 Rudolph, Stephanie
A1 Badura, Aleksandra
A1 Lutzu, Stefano
A1 Pathak, Salil Saurav
A1 Thieme, Andreas
A1 Verpeut, Jessica L.
A1 Wagner, Mark J.
A1 Yang, Yi-Mei
A1 Fioravante, Diasynou
YR 2023
UL http://www.jneurosci.org/content/43/45/7554.abstract
AB The cerebellum, traditionally associated with motor coordination and balance, also plays a crucial role in various aspects of higher-order function and dysfunction. Emerging research has shed light on the cerebellum's broader contributions to cognitive, emotional, and reward processes. The cerebellum's influence on autonomic function further highlights its significance in regulating motivational and emotional states. Perturbations in cerebellar development and function have been implicated in various neurodevelopmental disorders, including autism spectrum disorder and attention deficit hyperactivity disorder. An increasing appreciation for neuropsychiatric symptoms that arise from cerebellar dysfunction underscores the importance of elucidating the circuit mechanisms that underlie complex interactions between the cerebellum and other brain regions for a comprehensive understanding of complex behavior. By briefly discussing new advances in mapping cerebellar function in affective, cognitive, autonomic, and social processing and reviewing the role of the cerebellum in neuropathology beyond the motor domain, this Mini-Symposium review aims to provide a broad perspective of cerebellar intersections with the limbic brain in health and disease.