PT - JOURNAL ARTICLE AU - Kratsios, Paschalis AU - Zampieri, Niccolò AU - Carrillo, Robert AU - Mizumoto, Kota AU - Sweeney, Lora B. AU - Philippidou, Polyxeni TI - Molecular and Cellular Mechanisms of Motor Circuit Development AID - 10.1523/JNEUROSCI.1238-24.2024 DP - 2024 Oct 02 TA - The Journal of Neuroscience PG - e1238242024 VI - 44 IP - 40 4099 - http://www.jneurosci.org/content/44/40/e1238242024.short 4100 - http://www.jneurosci.org/content/44/40/e1238242024.full SO - J. Neurosci.2024 Oct 02; 44 AB - Motor circuits represent the main output of the central nervous system and produce dynamic behaviors ranging from relatively simple rhythmic activities like swimming in fish and breathing in mammals to highly sophisticated dexterous movements in humans. Despite decades of research, the development and function of motor circuits remain poorly understood. Breakthroughs in the field recently provided new tools and tractable model systems that set the stage to discover the molecular mechanisms and circuit logic underlying motor control. Here, we describe recent advances from both vertebrate (mouse, frog) and invertebrate (nematode, fruit fly) systems on cellular and molecular mechanisms that enable motor circuits to develop and function and highlight conserved and divergent mechanisms necessary for motor circuit development.