RT Journal Article
SR Electronic
T1 Molecular and Cellular Mechanisms of Motor Circuit Development
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP e1238242024
DO 10.1523/JNEUROSCI.1238-24.2024
VO 44
IS 40
A1 Kratsios, Paschalis
A1 Zampieri, Niccolò
A1 Carrillo, Robert
A1 Mizumoto, Kota
A1 Sweeney, Lora B.
A1 Philippidou, Polyxeni
YR 2024
UL http://www.jneurosci.org/content/44/40/e1238242024.abstract
AB Motor circuits represent the main output of the central nervous system and produce dynamic behaviors ranging from relatively simple rhythmic activities like swimming in fish and breathing in mammals to highly sophisticated dexterous movements in humans. Despite decades of research, the development and function of motor circuits remain poorly understood. Breakthroughs in the field recently provided new tools and tractable model systems that set the stage to discover the molecular mechanisms and circuit logic underlying motor control. Here, we describe recent advances from both vertebrate (mouse, frog) and invertebrate (nematode, fruit fly) systems on cellular and molecular mechanisms that enable motor circuits to develop and function and highlight conserved and divergent mechanisms necessary for motor circuit development.