Comparison of phenotypes reproduced in regional knock-out and rescued in regional re-expression of MeCP2 function
| Phenotype | NULL | CKO | RESCUE |
|---|---|---|---|
| Weight | ↑ | ↓ | ↑ |
| Temperature | ↓ | Normal | ND |
| Heart rate | ↓ | ↓ | Rescued |
| Basal breathing | ↑ | Normal | ↑ |
| Respiratory response to hypoxia | ↑ | ↑ | Rescued |
| Lifespan | ↓ | ↓ | Rescued |
In this table, an up arrow indicates increased amount of a particular phenotype, and a down arrow indicates a decreased amount. For example, weight was increased in NULL animals, decreased in CKO animals, and increased in Rescue animals. The phenotypes that are rescued (i.e., indistinguishable from WT) in the regional rescue experiment are listed as “rescued.” ND indicates not done.