Table 1.

Effects of MK801 and kindling on afterdischarge threshold (microamps ± SEM)

1st AD1_15010th AD11th AD17th AD1st class V2nd class V10th class V
Controls561  ± 42495  ± 39491  ± 40467  ± 79467  ± 47
1 class V
Controls562  ± 73490  ± 60484  ± 61437  ± 61435  ± 55417  ± 57314  ± 52
10 class V
MK8011007  ± 1331_151900  ± 102885  ± 106785  ± 100
0–17 ADs
MK801572  ± 49517  ± 44505  ± 49439  ± 42364  ± 35
10 ADs–1 class V
MK801594  ± 53575  ± 67566  ± 66455  ± 43471  ± 49453  ± 44282  ± 33
1–10 class V
  • F1_150 Versus final AD thresholds, F = 16.4, p = 0.0001, ANOVA;

  • F1_151 versus initial AD thresholds, F = 6.5, p = 0.0004, ANOVA.