Region | Basal | Stimulated | ||
---|---|---|---|---|
Control | Chronic Δ9-THC | Control | Chronic Δ9-THC | |
Hippocampus (D) | 100 ± 6% | 92 ± 4% | 181 ± 9% | 125 ± 7%† |
Hippocampus (M) | 100 ± 8% | 101 ± 6% | 188 ± 11% | 132 ± 10%† |
Hippocampus (V) | 100 ± 7% | 99 ± 4% | 196 ± 13% | 129 ± 8%‡ |
Perirhinal cortex (M) | 100 ± 6% | 94 ± 3% | 178 ± 11% | 127 ± 6%* |
Perirhinal cortex (V) | 100 ± 10% | 83 ± 2% | 166 ± 10% | 117 ± 6%† |
Entorhinal cortex (D) | 100 ± 5% | 96 ± 8% | 156 ± 7% | 133 ± 7%* |
Entorhinal cortex (M) | 100 ± 6% | 100 ± 2% | 174 ± 9% | 132 ± 3%‡ |
Entorhinal cortex (V) | 100 ± 10% | 108 ± 4% | 189 ± 14% | 144 ± 5%* |
Septum | 100 ± 7% | 104 ± 6% | 157 ± 12% | 144 ± 2% |
Caudate-putamen (D) | 100 ± 6% | 81 ± 9% | 191 ± 14% | 134 ± 4%† |
Caudate-putamen (M) | 100 ± 5% | 85 ± 2%* | 163 ± 12% | 118 ± 7%‡ |
Globus pallidus | 100 ± 8% | 73 ± 4%* | 362 ± 18% | 206 ± 19%‡ |
Substantia nigra | 100 ± 6% | 85 ± 8% | 484 ± 12% | 349 ± 11%‡ |
Cerebellum | 100 ± 5% | 123 ± 4%* | 185 ± 13% | 167 ± 12% |
PAG | 100 ± 8% | 92 ± 10% | 122 ± 4% | 114 ± 9% |
Sections were incubated with 2 mm GDP, and then with [35S]GTPγS (0.04 nm) and 2 mmGDP, with and without 10 μm WIN 55212-2. Data are expressed as percentage of control basal binding and represent mean values ± SE of duplicate sections from five animals. The level of the sections measured are dorsal (D), Figure 2 (top); midlevel (M), Figure2 (middle); and ventral (V), Figure 2 (bottom).
↵* p < 0.05;
↵† p < 0.01;
↵‡ p < 0.005.