Table 1.

Pharmacological analysis of the regulation of JAK2 immunoreactivity in the VTA

Control100  ± 12
Chronic cocaine148  ± 11*
Chronic–acute cocaine145  ± 14*
Acute cocaine96  ± 6
Chronic morphine105  ± 8
Chronic desipramine87  ± 16
Chronic fluvoxamine88  ± 17
Chronic CNTF136  ± 17*
Chronic BDNF93  ± 9

  • Treatment paradigms included chronic, chronic–acute, and acute cocaine, chronic desipramine, chronic fluvoxamine, chronic morphine, and chronic CNTF and BDNF infusions (see Materials and Methods). Data are expressed as mean ± SEM percent of control (

  • ↵* p < 0.05 vs control by χ2 test). The numbers of animals used without and with cocaine, respectively, are chronic (12, 12), chronic–acute (8, 8), and acute (5, 5); without and with desipramine (5, 5); without and with fluvoxamine (5, 5); without and with morphine (4, 4); without and with CNTF (4, 5); and without and with BDNF (4, 4).