Table 1.
Selectivity of α-conotoxins
| α-CTx | Sequence* | nAChR | IC50(nm) | Reference |
|---|---|---|---|---|
| Mii | GCCSNPVCHLEHSNLC | α3β2 | 0.5 | (Cartier et al., 1996a,b) |
| Mi | GRCCHPACGKNYSC | α1β1δγ | 10 | (Johnson et al., 1995) |
| Imi | GCCSDPRCAWRC | α7 | 220 | (Johnson et al., 1995) |
The disulfide bonding pattern is as follows:
The structurally related α-conotoxins are selective for the indicated nAChR subunits expressed in Xenopus oocytes. Clones for neuronal subunits were from rat and clones for muscle subunits were from mouse.
↵* The C-terminal α-carboxyl group of all these peptides is amidated.
