Table 2.

Effect of the duration of the stimulus-free interval on the behavioral seizure response

Animals with behavioral seizure score ≥ grade 3 (%)2-bMedian seizure score2-c
Stimulus-free interval2-anFirst trialLast trialRetestFirst trialLast trialRetest
1 week130.015.415.4111
2 weeks240.00.050.02-165112.52-165
3 weeks119.10.063.6*1132-165
4 weeks185.611.188.92-1681142-165
  • F2-a Mice were administered 10% flurothyl by inhalation until a sustained generalized seizure was expressed. Eight trials (intertrial interval, 24 hr) were followed by varying periods of nonexposure to the convulsant stimulus when the mouse was retested and the behavioral seizure score assigned.

  • F2-b Values are the percent of group total expressing a behavioral seizure score of grade 3 or higher. Asterisks indicate statistically significant differences between the retest trial and the last trial by the McNemar test;

  • * p < 0.05,

  • F2-165 p < 0.005,

    p < 0.001.

  • F2-168 p < 0.001.

  • F2-c Values are the median seizure scores. Asterisks indicate statistically significant differences between the retest trial and the last trial by the Wilcoxon signed-ranks test;