Table 3.

Effect of the number of generalized seizures on the behavioral seizure response

Animals with behavioral seizure score ≥ grade 3 (%)3-bMedian seizure score3-c
No. of seizures3-anFirst trialLast trialRetestFirst trialLast trialRetest
150.0xxx0.0111
260.00.016.7111.5
460.00.033.31123-150
660.00.033.31123-150
8185.611.188.93-1681143-165
  • F3-a Mice were administered 10% flurothyl by inhalation until a sustained generalized seizure was expressed. A single or multiple generalized seizures (intertrial interval, 24 hr) were followed 28 d later by a retest trial when the behavioral seizure score was assigned.

  • F3-b Values are the percent of group total expressing a behavioral seizure score of grade 3 or higher. Asterisks indicate statistically significant differences between the retest trial and the last trial by the McNemar test:

  • F3-168 p < 0.001.

  • F3-c Values are the median seizure scores. Asterisks indicate statistically significant differences between the retest trial and the last trial by the Wilcoxon signed-ranks test;

  • F3-150 p < 0.05,

  • F3-165 p < 0.001.