Table 2.

α2-Adrenergic receptor concentration in the hypothalamus and orbitofrontal cortex

Hypothalamus
NucleinAgnnAgnControl
 DM5263.10  ± 23.075261.66  ± 19.530
 VM4290.04  ± 26.343305.01  ± 24.151249.6  ± 0.00
 LAT10363.93  ± 51.125328.50  ± 26.013360.81  ± 95.76
 POST8172.53  ± 27.754120.75  ± 9.303181.41  ± 30.06
Orbitofrontal cortex
LayernAgnnAgnControl
 I4630.45  ± 44.464680.16  ± 89.764775.20  ± 69.93
 III4472.44  ± 26.224453.36  ± 40.594488.25  ± 32.88
 IV4382.35  ± 24.784390.99  ± 36.274392.70  ± 30.15
 V–VI4358.95  ± 20.224351.15  ± 28.144362.25  ± 36.33
  • Densities of α2-adrenergic receptors in orbitofrontal cortex and in nuclei of the hypothalamus of Alzheimer’s disease patients with (AD-Ag) and without (AD-nAg) a history of aggression, and in normal age-matched controls, in femtomoles/mg protein ± SEM. No significant differences were found in receptor densities among the three groups of patients either in orbitofrontal (chosen for illustration) or dorsolateral prefrontal cortices or in the hypothalamus. DM, Dorsomedial nucleus; VM, ventromedial nucleus; LAT, lateral nucleus; POST, posterior nucleus.