Table 1.

Distribution of immunoreactivity for presynaptic mGluRs in excitatory pathways in the hippocampus

SubtypePP (CA1)PP (CA3)PP (DG)MFA/C (CA3)Sch
mGluR2+++++(medial)++(medial)++
mGluR7a+++++(medial)++(medial)+1-a++++
++(lateral)+(lateral)
mGluR7b++1-a
mGluR8+(lateral)+(lateral)
  • Immunoreactivity: +++, very strong; ++, strong; + moderate to weak; −, very weak, if any. A/C, Associational and commissural fibers; MF, mossy fiber; PP, perforant path; Sch, Schaffer collateral. Medial, lateral: prominent in medial or lateral perforant path terminal zone.

  • F1-a  Immunoreactivity is mostly present in synapses on interneurons.