Table 3.

Number of N/P ganglion neurons remaining in knockout or double-knockout mice at birth

GenotypeTotal number of neuronsPercent of wild type
Wild type (n = 6)3976  ± 294100
nt3+/− (n = 4)2711  ± 251683-150
nt3−/− (n = 6)2331  ± 222593-160
bdnf+/− (n = 4)2590  ± 145653-150
bdnf−/− (n = 8)1645  ± 194413-160
nt4+/−(n = 2)3265  ± 20182
nt4−/− (n = 8)1651  ± 357423-160
nt3−/−/bdnf−/−(n = 6)1340  ± 145343-150
bdnf+/−/nt4+/−(n = 4)2758  ± 126693-150
bdnf−/−/nt4−/−(n = 4)720  ± 80183-160
  • Number of N/P ganglion neurons at birth innt3−/−,bdnf−/−, andnt4−/− mice and double-mutant mice (± SEM).n = number of ganglia counted. Student’s ttest.

  • F3-150  p < 0.05;

  • F3-160  p < 0.01.