Single channel properties of native and αS247F mutant human α4β2 AChRs
| AChR | Channel amplitudes (pA) (at −80 mV) (SE) | Mean channel open times (msec) (SE) | |||
|---|---|---|---|---|---|
| τ1 | τ2 | ||||
| Mutant α4β2 | γ1 | 0.90 | 1.93 | 4.05 | |
| (0.01) | (0.37) | (0.24) | |||
| Native α4β2 | γ1 | 1.35 | 3.65 | 23.4 | |
| (0.06) | (0.51) | (4.76) | |||
| γ2 | 2.27 | 1.9 | 8.05 | ||
| (0.08) | (0.21) | (0.58) | |||