Relative effect of gene mutations
| Species | Mutation | Layer I | Hippocampus | Cerebellum |
|---|---|---|---|---|
| Mouse | Reeler (Reelin) | +++ | +++ | +++ |
| Scrambler (mDab1) | +++ | +++ | ++ | |
| Cdk5 mutation | +++ | +++ | +? | |
| P35 mutation | − | ± | ± | |
| Human | LIS1 mutation | − | ++ | ± |
| DC/XLIS (Doublin) | − | ++ | ± |
Different mutations are associated with varying degrees of abnormality in the cortex, cerebellum, and hippocampus. See further details in Discussion.