Table 1.

Effects of alaproclate microinjection on copulation

Brain regionDose (μg/μl)MLILEL
LHAA0.0166.3  ± 50.5315.9  ± 75.9450.5  ± 50.4
10.0548.2  ± 186.7859.2  ± 199.4*1104.3  ± 185.4*
20.0849.2  ± 195.6*1196.0  ± 176.1*1088.2  ± 182.2*
MPOA0.0251.9  ± 97.7384.6  ± 117.2793.3  ± 133.8
10.0337.3  ± 115.5525.1  ± 130.9680.8  ± 120.4
20.0457.8  ± 134.9722.4  ± 158.6889.8  ± 146.2
  • Values are means ± SE for mount, intromission, and ejaculation latencies (ML, IL, and EL, respectively) from 12 subjects (LHAA group) and 16 subjects (MPOA group) after three doses of alaproclate microinjected bilaterally into the LHAA or unilaterally into the MPOA. The 10 and 20 μg doses significantly increased latencies for behavioral parameters when microinjected into the LHAA, compared with the 0.0 μg group. No significant changes in mean latencies were observed when alaproclate was microinjected into the MPOA.

  • *  p < 0.05 versus 0.0 μg.